NON-SMALL CELL LUNG CANCER (NSCLC), EGFR DOWNSTREAM PATHWAY ACTIVATION AND TKI TARGETED THERAPIES SENSITIVITY: EFFECT OF THE PLASMA MEMBRANE-ASSOCIATED NEU3.

Adenocarcinoma of Non-Small Cell Lung Cancer (NSCLC) is a severe disease.Patients carrying EGFR mutations may benefit from EGFR targeted therapies (e.g.: gefitinib).Recently, it has been shown that sialidase NEU3 directly interacts and regulates EGFR.In this work, we investigate the effect of sialidase NEU3 overexpression on EGFR pathways activatio

A group of variously colored proteins belonging to the green fluorescent protein (GFP) family are responsible for coloring coral tissues.Corals of the Great Barrier Reef were studied with the custom-built fiber laser fluorescence spectrometers.Spectral analysis showed that most of the examined corals contained PCA hats multiple fluorescent peaks ra

Hehua Li,1,* Yaping Zhang,2,3,* Honggang Wang,4 Jing Liang,4 Yongjie Zhou,2,3 Yuanyuan Huang,1 Tianyi Zhai,1 Qiong Yang,1 Mingzhe Yang,1 Yuping Ning,1,5 Hongbo He,1 Kai Wu,6 Fengjuan Chen,7 Fengchun Wu,1,5,8 Xiangyang Zhang1,9 1Department of Psychiatry, The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou, People’s Republi

Inflammation is a crucial factor in cardiac remodeling after acute myocardial infarction (MI).Neutrophils, as the first wave of leukocytes to infiltrate the injured myocardium, exacerbate inflammation and cardiac injury.However, therapies that deplete neutrophils to manage cardiac remodeling after MI have toe clip not consistently produced promisin